This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for RBM45. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM45 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM45, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:178,072,062–178,073,552 | 53.3 kb | Distal (>10kb) Multiome | 913 | |
| chr2:178,088,991–178,089,963 | 36.6 kb | Distal (>10kb) Multiome | 100 | |
| chr2:178,112,051–178,113,183 | 13.7 kb | Distal (>10kb) Multiome | 1042 | |
| chr2:178,132,380–178,132,974 | 6.2 kb | Proximal (<10kb) | 180 | |
| chr2:178,193,538–178,195,689 | 68.3 kb | Distal (>10kb) Multiome | 876 | |
| chr2:178,211,552–178,212,360 | 86.0 kb | Distal (>10kb) Multiome | 170 | |
| chr2:178,413,219–178,414,399 | 287.6 kb | Distal (>10kb) Multiome HiCAR | 734 | |
| chr2:178,414,525–178,415,185 | 288.8 kb | Distal (>10kb) Multiome HiCAR | 748 |
Genomic view of the RBM45 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.