Predicted to enable RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RBM43. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM43 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM43, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:149,587,059–149,588,359 | 1674.0 kb | Distal (>10kb) Multiome HiCAR | 991 | |
| chr2:151,261,080–151,262,216 | 104 bp | At TSS Multiome | 869 | |
| chr2:151,288,727–151,290,005 | 27.7 kb | Distal (>10kb) Multiome | 858 | |
| chr2:151,408,735–151,410,773 | 147.1 kb | Distal (>10kb) Multiome | 1137 |
Genomic view of the RBM43 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.