Enables mRNA 3'-UTR binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of cell population proliferation; and regulation of gene expression. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RBM38. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM38 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM38, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:57,231,910–57,232,397 | 159.2 kb | Distal (>10kb) Multiome | 241 | |
| chr20:57,263,861–57,265,018 | 127.0 kb | Distal (>10kb) Multiome | 521 | |
| chr20:57,265,156–57,267,217 | 124.8 kb | Distal (>10kb) Multiome | 462 | |
| chr20:57,323,005–57,323,752 | 68.1 kb | Distal (>10kb) Multiome | 226 | |
| chr20:57,350,979–57,351,567 | 40.1 kb | Distal (>10kb) Multiome | 833 | |
| chr20:57,381,847–57,382,046 | 9.3 kb | Proximal (<10kb) | 285 | |
| chr20:57,389,119–57,389,876 | 2.0 kb | Proximal (<10kb) Multiome | 590 | |
| chr20:57,390,113–57,392,016 | 49 bp | At TSS Multiome | 692 | |
| chr20:57,596,872–57,597,457 | 205.8 kb | Distal (>10kb) Multiome | 473 |
Genomic view of the RBM38 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.