Transcription factors with Perturb-seq knockdown data for RBM33-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM33-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM33-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:155,344,600–155,345,572 | 300.2 kb | Distal (>10kb) Multiome | 521 | |
| chr7:155,380,186–155,380,859 | 264.7 kb | Distal (>10kb) Multiome | 306 | |
| chr7:155,456,809–155,459,720 | 187.7 kb | Distal (>10kb) Multiome | 434 | |
| chr7:155,466,156–155,467,479 | 178.3 kb | Distal (>10kb) Multiome | 270 | |
| chr7:155,467,594–155,468,737 | 177.0 kb | Distal (>10kb) Multiome | 231 | |
| chr7:155,509,435–155,510,584 | 135.1 kb | Distal (>10kb) Multiome | 392 | |
| chr7:155,533,097–155,534,150 | 111.3 kb | Distal (>10kb) Multiome | 391 | |
| chr7:155,643,919–155,645,325 | 688 bp | At TSS Multiome | 927 | |
| chr7:155,680,569–155,681,472 | 35.8 kb | Distal (>10kb) Multiome | 193 | |
| chr7:155,787,041–155,788,180 | 142.3 kb | Distal (>10kb) Multiome | 206 | |
| chr7:155,796,797–155,797,641 | 152.0 kb | Distal (>10kb) Multiome | 291 | |
| chr7:155,802,850–155,806,571 | 158.6 kb | Distal (>10kb) Multiome | 556 |
Genomic view of the RBM33-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.