This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RBM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:48,475,845–48,476,469 | 98.3 kb | Distal (>10kb) Multiome | 613 | |
| chrX:48,508,766–48,509,247 | 65.6 kb | Distal (>10kb) Multiome | 400 | |
| chrX:48,521,369–48,522,158 | 52.7 kb | Distal (>10kb) Multiome | 519 | |
| chrX:48,539,185–48,540,294 | 34.9 kb | Distal (>10kb) Multiome | 658 | |
| chrX:48,574,090–48,575,023 | 93 bp | At TSS Multiome | 779 | |
| chrX:48,597,350–48,598,476 | 23.4 kb | Distal (>10kb) Multiome | 660 | |
| chrX:48,676,132–48,677,132 | 102.0 kb | Distal (>10kb) Multiome | 642 | |
| chrX:48,695,862–48,697,105 | 122.2 kb | Distal (>10kb) Multiome | 600 | |
| chrX:48,737,116–48,737,756 | 162.9 kb | Distal (>10kb) Multiome | 580 | |
| chrX:48,801,126–48,802,845 | 227.4 kb | Distal (>10kb) Multiome | 734 |
Genomic view of the RBM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.