This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for RBM17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:5,812,699–5,814,342 | 275.5 kb | Distal (>10kb) Multiome | 1126 | |
| chr10:5,866,673–5,867,954 | 221.7 kb | Distal (>10kb) Multiome | 153 | |
| chr10:5,888,755–5,891,014 | 199.0 kb | Distal (>10kb) Multiome | 918 | |
| chr10:5,976,561–5,978,337 | 111.1 kb | Distal (>10kb) Multiome | 723 | |
| chr10:6,086,345–6,087,026 | 2.5 kb | Proximal (<10kb) Multiome | 467 | |
| chr10:6,088,532–6,090,276 | 77 bp | At TSS Multiome | 847 | |
| chr10:6,108,563–6,109,206 | 19.8 kb | Distal (>10kb) Multiome | 207 | |
| chr10:6,144,513–6,146,019 | 55.9 kb | Distal (>10kb) Multiome | 592 | |
| chr10:6,151,133–6,151,901 | 62.5 kb | Distal (>10kb) Multiome | 300 | |
| chr10:6,163,382–6,164,228 | 74.7 kb | Distal (>10kb) Multiome | 706 | |
| chr10:6,184,834–6,185,745 | 96.3 kb | Distal (>10kb) Multiome | 123 | |
| chr10:6,200,717–6,205,207 | 112.5 kb | Distal (>10kb) Multiome | 1010 |
Genomic view of the RBM17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.