Transcription factors with Perturb-seq knockdown data for RBM12B-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM12B-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM12B-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:93,731,017–93,731,276 | 9.9 kb | Proximal (<10kb) | 128 | |
| chr8:93,740,245–93,741,472 | at TSS | At TSS | 876 | |
| chr8:93,746,443–93,746,614 | 5.3 kb | Proximal (<10kb) | 31 | |
| chr8:93,748,775–93,749,056 | 7.6 kb | Proximal (<10kb) | 127 | |
| chr8:93,750,573–93,751,014 | 9.4 kb | Proximal (<10kb) | 27 |
Genomic view of the RBM12B-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.