Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RASGEF1C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASGEF1C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASGEF1C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:180,071,104–180,072,473 | 137.2 kb | Distal (>10kb) Multiome | 1084 | |
| chr5:180,090,117–180,091,054 | 118.7 kb | Distal (>10kb) Multiome | 575 | |
| chr5:180,201,343–180,201,534 | 7.7 kb | Proximal (<10kb) | 78 | |
| chr5:180,208,671–180,209,518 | 56 bp | At TSS Multiome | 385 | |
| chr5:180,291,390–180,292,854 | 82.9 kb | Distal (>10kb) Multiome | 694 | |
| chr5:180,292,972–180,293,953 | 84.4 kb | Distal (>10kb) Multiome | 556 | |
| chr5:180,352,255–180,354,009 | 144.3 kb | Distal (>10kb) Multiome | 450 | |
| chr5:180,493,929–180,495,203 | 285.1 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the RASGEF1C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.