Enables guanyl-nucleotide exchange factor activity. Involved in cell migration and positive regulation of Ras protein signal transduction. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RASGEF1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASGEF1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASGEF1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:42,932,398–42,934,239 | 270.9 kb | Distal (>10kb) Multiome | 252 | |
| chr10:42,951,596–42,953,009 | 251.4 kb | Distal (>10kb) Multiome | 263 | |
| chr10:43,026,131–43,027,199 | 177.1 kb | Distal (>10kb) Multiome | 308 | |
| chr10:43,076,256–43,078,068 | 126.8 kb | Distal (>10kb) Multiome | 337 | |
| chr10:43,104,555–43,106,082 | 98.3 kb | Distal (>10kb) Multiome | 582 | |
| chr10:43,137,532–43,139,055 | 65.3 kb | Distal (>10kb) Multiome | 754 | |
| chr10:43,202,016–43,204,485 | 218 bp | At TSS Multiome | 505 | |
| chr10:43,204,643–43,205,459 | 1.4 kb | Proximal (<10kb) Multiome | 272 | |
| chr10:43,228,465–43,230,305 | 26.0 kb | Distal (>10kb) Multiome | 290 | |
| chr10:43,265,915–43,267,309 | 63.1 kb | Distal (>10kb) Multiome | 244 | |
| chr10:43,322,425–43,323,518 | 119.2 kb | Distal (>10kb) Multiome | 215 | |
| chr10:43,361,820–43,362,935 | 158.6 kb | Distal (>10kb) Multiome | 416 | |
| chr10:43,395,694–43,397,607 | 193.3 kb | Distal (>10kb) Multiome | 1120 | |
| chr10:43,407,131–43,410,086 | 205.4 kb | Distal (>10kb) Multiome | 1109 | |
| chr10:43,420,185–43,421,230 | 216.9 kb | Distal (>10kb) Multiome | 1071 | |
| chr10:43,436,316–43,437,609 | 233.1 kb | Distal (>10kb) Multiome | 970 | |
| chr10:43,455,021–43,456,361 | 251.9 kb | Distal (>10kb) Multiome | 973 |
Genomic view of the RASGEF1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.