The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for RASAL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASAL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASAL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:113,092,863–113,093,647 | 42.5 kb | Distal (>10kb) Multiome | 192 | |
| chr12:113,103,783–113,104,453 | 31.7 kb | Distal (>10kb) Multiome | 273 | |
| chr12:113,135,292–113,136,333 | 81 bp | At TSS Multiome | 375 | |
| chr12:113,149,367–113,149,817 | 13.9 kb | Distal (>10kb) Multiome HiCAR | 206 | |
| chr12:113,152,822–113,153,581 | 17.4 kb | Distal (>10kb) Multiome HiCAR | 573 | |
| chr12:113,154,377–113,154,958 | 19.0 kb | Distal (>10kb) Multiome HiCAR | 182 | |
| chr12:113,161,407–113,162,141 | 26.0 kb | Distal (>10kb) Multiome | 235 | |
| chr12:113,184,669–113,186,034 | 49.8 kb | Distal (>10kb) Multiome | 1020 | |
| chr12:113,220,621–113,222,139 | 85.6 kb | Distal (>10kb) Multiome | 818 | |
| chr12:113,245,518–113,246,307 | 110.2 kb | Distal (>10kb) Multiome | 649 | |
| chr12:113,334,690–113,335,505 | 199.4 kb | Distal (>10kb) Multiome | 685 | |
| chr12:113,358,144–113,359,258 | 222.8 kb | Distal (>10kb) Multiome | 774 |
Genomic view of the RASAL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.