Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RAPGEFL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAPGEFL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAPGEFL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:39,926,716–39,928,343 | 249.8 kb | Distal (>10kb) Multiome | 942 | |
| chr17:39,952,356–39,953,923 | 224.3 kb | Distal (>10kb) Multiome | 598 | |
| chr17:39,979,964–39,981,234 | 196.9 kb | Distal (>10kb) Multiome | 1148 | |
| chr17:40,054,311–40,054,810 | 123.0 kb | Distal (>10kb) Multiome | 694 | |
| chr17:40,062,700–40,063,624 | 114.5 kb | Distal (>10kb) Multiome | 609 | |
| chr17:40,075,390–40,075,997 | 101.8 kb | Distal (>10kb) Multiome | 556 | |
| chr17:40,098,950–40,099,858 | 78.2 kb | Distal (>10kb) Multiome | 997 | |
| chr17:40,100,155–40,101,301 | 76.7 kb | Distal (>10kb) Multiome | 954 | |
| chr17:40,111,702–40,112,164 | 65.6 kb | Distal (>10kb) Multiome | 678 | |
| chr17:40,113,185–40,113,691 | 64.1 kb | Distal (>10kb) Multiome | 864 | |
| chr17:40,121,452–40,123,602 | 55.6 kb | Distal (>10kb) Multiome | 799 | |
| chr17:40,139,909–40,141,108 | 37.1 kb | Distal (>10kb) Multiome | 1121 | |
| chr17:40,177,152–40,178,398 | 16 bp | At TSS Multiome | 329 | |
| chr17:40,190,510–40,190,710 | 758 bp | At TSS | 204 | |
| chr17:40,191,326–40,192,022 | 14.3 kb | Distal (>10kb) Multiome | 588 | |
| chr17:40,218,712–40,219,963 | 41.9 kb | Distal (>10kb) Multiome | 901 | |
| chr17:40,287,308–40,288,608 | 110.3 kb | Distal (>10kb) Multiome | 870 | |
| chr17:40,306,565–40,307,697 | 129.6 kb | Distal (>10kb) Multiome | 366 | |
| chr17:40,316,576–40,317,119 | 139.3 kb | Distal (>10kb) Multiome | 557 | |
| chr17:40,317,794–40,318,727 | 140.7 kb | Distal (>10kb) Multiome | 799 | |
| chr17:40,341,205–40,342,644 | 164.5 kb | Distal (>10kb) Multiome | 835 | |
| chr17:40,344,939–40,346,042 | 167.9 kb | Distal (>10kb) Multiome | 730 | |
| chr17:40,362,469–40,363,831 | 185.4 kb | Distal (>10kb) Multiome | 846 | |
| chr17:40,417,289–40,418,494 | 240.6 kb | Distal (>10kb) Multiome | 793 | |
| chr17:40,422,953–40,423,555 | 245.7 kb | Distal (>10kb) Multiome | 242 | |
| chr17:40,442,866–40,444,146 | 266.0 kb | Distal (>10kb) Multiome | 774 | |
| chr17:42,016,953–42,018,102 | 1840.0 kb | Distal (>10kb) Multiome HiCAR | 991 | |
| chr17:42,019,726–42,020,334 | 1842.6 kb | Distal (>10kb) Multiome HiCAR | 791 |
Genomic view of the RAPGEFL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.