The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for RAD51D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAD51D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAD51D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:34,886,833–34,887,368 | 232.7 kb | Distal (>10kb) Multiome | 205 | |
| chr17:34,961,027–34,961,847 | 158.3 kb | Distal (>10kb) Multiome | 793 | |
| chr17:34,980,134–34,981,317 | 139.1 kb | Distal (>10kb) Multiome HiCAR | 855 | |
| chr17:35,063,589–35,064,217 | 56.0 kb | Distal (>10kb) Multiome | 813 | |
| chr17:35,088,426–35,090,139 | 30.5 kb | Distal (>10kb) Multiome | 805 | |
| chr17:35,119,302–35,120,200 | 20 bp | At TSS Multiome | 761 | |
| chr17:35,141,908–35,142,655 | 22.5 kb | Distal (>10kb) Multiome | 873 | |
| chr17:35,242,191–35,243,858 | 123.1 kb | Distal (>10kb) Multiome | 590 | |
| chr17:35,312,777–35,313,483 | 193.2 kb | Distal (>10kb) Multiome | 263 |
Genomic view of the RAD51D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.