Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RAB42. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB42 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB42, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:28,369,387–28,370,499 | 222.4 kb | Distal (>10kb) Multiome | 961 | |
| chr1:28,505,412–28,506,885 | 86.3 kb | Distal (>10kb) Multiome | 969 | |
| chr1:28,513,136–28,516,505 | 76.7 kb | Distal (>10kb) Multiome | 461 | |
| chr1:28,517,302–28,519,364 | 73.9 kb | Distal (>10kb) Multiome | 927 | |
| chr1:28,552,370–28,553,806 | 39.2 kb | Distal (>10kb) Multiome | 955 | |
| chr1:28,580,985–28,582,501 | 10.3 kb | Distal (>10kb) Multiome | 1080 | |
| chr1:28,582,603–28,583,287 | 8.9 kb | Proximal (<10kb) | 171 | |
| chr1:28,592,018–28,592,768 | 112 bp | At TSS Multiome | 394 | |
| chr1:28,642,403–28,643,726 | 50.9 kb | Distal (>10kb) Multiome | 980 | |
| chr1:28,648,003–28,650,002 | 56.6 kb | Distal (>10kb) Multiome | 1377 | |
| chr1:28,667,742–28,669,783 | 76.7 kb | Distal (>10kb) Multiome | 804 | |
| chr1:28,736,098–28,738,080 | 144.5 kb | Distal (>10kb) Multiome | 1106 | |
| chr1:28,811,880–28,812,661 | 220.1 kb | Distal (>10kb) Multiome | 219 | |
| chr1:28,881,894–28,882,433 | 290.1 kb | Distal (>10kb) Multiome | 615 | |
| chr1:28,886,723–28,888,425 | 294.8 kb | Distal (>10kb) Multiome | 709 |
Genomic view of the RAB42 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.