RAB40C
RAB40C, member RAS oncogene family | RARL, RASL8C

Predicted to enable GTPase activity. Predicted to be involved in exocytosis. Located in Golgi apparatus and lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 26 terms
Cul5-RING ubiquitin ligase complex (GO:0031466)G protein activity (GO:0003925)G protein activity (GO:0003925)GTP binding (GO:0005525)GTPase activity (GO:0003924)GTPase activity (GO:0003924)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)cell migration (GO:0016477)cytosol (GO:0005829)cytosol (GO:0005829)endosome (GO:0005768)exocytosis (GO:0006887)intracellular signal transduction (GO:0035556)lipid droplet (GO:0005811)lipid droplet (GO:0005811)lipid droplet formation (GO:0140042)negative regulation of focal adhesion assembly (GO:0051895)plasma membrane (GO:0005886)plasma membrane (GO:0005886)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein ubiquitination (GO:0016567)synaptic vesicle (GO:0008021)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)
Expression (TPM)
RAB40C — as a Regulated Gene

TFs regulating RAB40C 0 TFs

Transcription factors with Perturb-seq knockdown data for RAB40C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB40C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RAB40C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB40C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:351,804–354,436 236.4 kb Distal (>10kb) Multiome 654
chr16:378,999–379,813 210.0 kb Distal (>10kb) Multiome 225
chr16:380,836–382,614 207.4 kb Distal (>10kb) Multiome HiCAR 634
chr16:383,438–384,218 205.5 kb Distal (>10kb) Multiome HiCAR 342
chr16:396,893–397,640 191.9 kb Distal (>10kb) Multiome HiCAR 496
chr16:401,380–402,199 187.5 kb Distal (>10kb) Multiome 818
chr16:424,888–426,136 163.8 kb Distal (>10kb) Multiome 752
chr16:483,333–484,000 105.6 kb Distal (>10kb) Multiome 143
chr16:526,749–528,601 61.8 kb Distal (>10kb) Multiome 811
chr16:569,530–570,338 19.5 kb Distal (>10kb) Multiome 492
chr16:578,896–579,353 10.2 kb Distal (>10kb) Multiome 511
chr16:588,593–590,724 521 bp At TSS Multiome 853
chr16:635,900–638,127 47.0 kb Distal (>10kb) Multiome 1021
chr16:641,491–643,007 52.5 kb Distal (>10kb) Multiome 856
chr16:648,795–649,829 59.9 kb Distal (>10kb) Multiome 862
chr16:660,457–661,656 71.6 kb Distal (>10kb) Multiome 456
chr16:667,633–668,442 78.7 kb Distal (>10kb) Multiome 838
chr16:678,847–681,585 90.7 kb Distal (>10kb) Multiome HiCAR 803
chr16:683,618–684,859 95.0 kb Distal (>10kb) Multiome 701
chr16:694,897–695,485 106.1 kb Distal (>10kb) Multiome 390
chr16:705,242–706,468 116.6 kb Distal (>10kb) Multiome 248
chr16:714,577–716,048 125.7 kb Distal (>10kb) Multiome 555
chr16:720,434–721,963 132.0 kb Distal (>10kb) Multiome 966
chr16:726,310–729,144 137.7 kb Distal (>10kb) Multiome 736
chr16:740,359–741,596 151.7 kb Distal (>10kb) Multiome 897
chr16:787,564–789,160 199.1 kb Distal (>10kb) Multiome 635
chr16:807,352–808,044 218.5 kb Distal (>10kb) Multiome 600
chr16:813,330–813,960 224.4 kb Distal (>10kb) Multiome 325

Genome Browser

Genomic view of the RAB40C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:341,804 – 823,960
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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