This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion and endocytosis. Rab GTPases are active, membrane-associated proteins that recruit effector proteins in the GTP-bound state and inactive cytosolic proteins when in a GDP-bound state. The protein encoded by this gene is ubiquitously expressed and has been implicated in Golgi to endoplasmic reticulum cycling of Golgi enzymes. In addition, this protein regulates Golgi homeostasis and coordinates intra-Golgi retrograde trafficking. Allelic variants in this gene have been associated with Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia 2, which are autosomal recessive spondyloepimetaphyseal dysplasias characterized by skeletal abnormalities. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for RAB33B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB33B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB33B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:139,159,062–139,160,313 | 294.4 kb | Distal (>10kb) Multiome | 133 | |
| chr4:139,176,009–139,179,224 | 276.1 kb | Distal (>10kb) Multiome | 1018 | |
| chr4:139,279,361–139,280,628 | 173.9 kb | Distal (>10kb) Multiome | 287 | |
| chr4:139,295,267–139,296,002 | 158.3 kb | Distal (>10kb) Multiome | 947 | |
| chr4:139,300,735–139,302,627 | 152.8 kb | Distal (>10kb) Multiome | 912 | |
| chr4:139,453,063–139,454,584 | 276 bp | At TSS Multiome | 989 | |
| chr4:139,461,123–139,461,280 | 7.0 kb | Proximal (<10kb) | 21 | |
| chr4:139,555,161–139,557,952 | 101.3 kb | Distal (>10kb) Multiome | 818 | |
| chr4:139,656,647–139,657,308 | 202.9 kb | Distal (>10kb) Multiome | 322 | |
| chr4:139,665,282–139,666,449 | 211.7 kb | Distal (>10kb) Multiome | 844 | |
| chr4:139,667,275–139,669,052 | 214.2 kb | Distal (>10kb) Multiome | 181 | |
| chr4:139,669,155–139,671,298 | 215.8 kb | Distal (>10kb) Multiome | 252 | |
| chr4:139,734,753–139,735,998 | 281.0 kb | Distal (>10kb) Multiome | 441 |
Genomic view of the RAB33B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.