Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]
Transcription factors with Perturb-seq knockdown data for RAB2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:21,191,911–21,192,845 | 284.8 kb | Distal (>10kb) Multiome | 463 | |
| chr14:21,268,822–21,270,154 | 207.3 kb | Distal (>10kb) Multiome | 1029 | |
| chr14:21,308,204–21,309,328 | 168.1 kb | Distal (>10kb) Multiome | 647 | |
| chr14:21,383,896–21,384,850 | 92.7 kb | Distal (>10kb) Multiome | 931 | |
| chr14:21,436,834–21,437,890 | 39.6 kb | Distal (>10kb) Multiome | 875 | |
| chr14:21,455,683–21,456,683 | 20.7 kb | Distal (>10kb) Multiome | 862 | |
| chr14:21,476,573–21,477,687 | 76 bp | At TSS Multiome | 931 | |
| chr14:21,510,804–21,511,761 | 34.5 kb | Distal (>10kb) Multiome | 972 | |
| chr14:21,525,630–21,527,355 | 49.5 kb | Distal (>10kb) Multiome | 627 | |
| chr14:21,534,439–21,535,312 | 57.9 kb | Distal (>10kb) Multiome | 146 | |
| chr14:21,536,256–21,537,359 | 60.0 kb | Distal (>10kb) Multiome | 181 | |
| chr14:21,557,417–21,557,905 | 80.7 kb | Distal (>10kb) Multiome | 526 |
Genomic view of the RAB2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.