Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for RAB26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:1,918,171–1,918,773 | 230.2 kb | Distal (>10kb) Multiome | 129 | |
| chr16:1,929,283–1,930,271 | 218.8 kb | Distal (>10kb) Multiome | 780 | |
| chr16:1,942,671–1,943,761 | 205.2 kb | Distal (>10kb) Multiome | 750 | |
| chr16:1,958,923–1,960,140 | 189.1 kb | Distal (>10kb) Multiome | 826 | |
| chr16:1,964,300–1,965,434 | 183.7 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,971,481–1,972,435 | 176.7 kb | Distal (>10kb) Multiome | 1010 | |
| chr16:1,979,111–1,980,324 | 169.3 kb | Distal (>10kb) Multiome | 296 | |
| chr16:1,983,450–1,984,851 | 164.6 kb | Distal (>10kb) Multiome | 917 | |
| chr16:1,989,307–1,993,568 | 158.4 kb | Distal (>10kb) Multiome | 706 | |
| chr16:2,003,882–2,004,348 | 144.6 kb | Distal (>10kb) Multiome | 619 | |
| chr16:2,009,742–2,010,504 | 138.8 kb | Distal (>10kb) Multiome HiCAR | 752 | |
| chr16:2,022,700–2,023,923 | 125.3 kb | Distal (>10kb) Multiome HiCAR | 682 | |
| chr16:2,026,629–2,027,149 | 121.8 kb | Distal (>10kb) Multiome HiCAR | 249 | |
| chr16:2,047,366–2,048,252 | 100.8 kb | Distal (>10kb) Multiome | 875 | |
| chr16:2,090,476–2,092,232 | 57.3 kb | Distal (>10kb) Multiome | 344 | |
| chr16:2,135,536–2,136,505 | 12.5 kb | Distal (>10kb) Multiome | 263 | |
| chr16:2,147,864–2,149,260 | 147 bp | At TSS Multiome | 679 | |
| chr16:2,149,550–2,152,180 | 2.4 kb | Proximal (<10kb) Multiome | 618 | |
| chr16:2,152,861–2,153,999 | 4.2 kb | Proximal (<10kb) | 734 | |
| chr16:2,154,834–2,156,329 | 7.0 kb | Proximal (<10kb) Multiome | 932 | |
| chr16:2,178,140–2,179,722 | 30.1 kb | Distal (>10kb) Multiome | 318 | |
| chr16:2,205,129–2,206,297 | 56.8 kb | Distal (>10kb) Multiome | 887 | |
| chr16:2,214,212–2,215,803 | 66.4 kb | Distal (>10kb) Multiome | 953 | |
| chr16:2,223,095–2,224,285 | 74.8 kb | Distal (>10kb) Multiome | 918 | |
| chr16:2,251,044–2,252,460 | 103.1 kb | Distal (>10kb) Multiome | 996 | |
| chr16:2,267,625–2,269,111 | 119.6 kb | Distal (>10kb) Multiome | 1044 | |
| chr16:2,339,631–2,342,283 | 192.2 kb | Distal (>10kb) Multiome | 1129 | |
| chr16:2,428,282–2,429,948 | 280.6 kb | Distal (>10kb) Multiome | 827 |
Genomic view of the RAB26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.