QPCTL

glutaminyl-peptide cyclotransferase like | FLJ20084

Enables glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 11 terms

Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)glutaminyl-peptide cyclotransferase activity (GO:0016603)glutaminyl-peptide cyclotransferase activity (GO:0016603)glutaminyl-peptide cyclotransferase activity (GO:0016603)membrane (GO:0016020)peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase (GO:0017186)peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase (GO:0017186)protein binding (GO:0005515)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating QPCTL 0 TFs

Transcription factors with Perturb-seq knockdown data for QPCTL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = QPCTL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to QPCTL

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of QPCTL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:45,402,280–45,402,828	290.1 kb	Distal (>10kb) Multiome	332
chr19:45,403,781–45,404,684	288.7 kb	Distal (>10kb) Multiome	494
chr19:45,404,818–45,406,887	286.2 kb	Distal (>10kb) Multiome	964
chr19:45,423,326–45,424,545	268.9 kb	Distal (>10kb) Multiome	996
chr19:45,439,539–45,440,189	252.8 kb	Distal (>10kb) Multiome	718
chr19:45,443,052–45,444,768	249.2 kb	Distal (>10kb) Multiome	857
chr19:45,450,695–45,451,265	241.8 kb	Distal (>10kb) Multiome	515
chr19:45,455,706–45,456,201	236.7 kb	Distal (>10kb) Multiome	776
chr19:45,467,169–45,468,696	224.9 kb	Distal (>10kb) Multiome	686
chr19:45,468,843–45,470,312	223.2 kb	Distal (>10kb) Multiome	769
chr19:45,478,416–45,479,276	213.9 kb	Distal (>10kb) Multiome	809
chr19:45,485,144–45,486,070	207.1 kb	Distal (>10kb) Multiome	659
chr19:45,492,647–45,493,344	199.8 kb	Distal (>10kb) Multiome	522
chr19:45,496,247–45,497,677	195.6 kb	Distal (>10kb) Multiome	742
chr19:45,498,270–45,499,916	193.1 kb	Distal (>10kb) Multiome	464
chr19:45,506,243–45,507,963	185.9 kb	Distal (>10kb) Multiome	969
chr19:45,508,291–45,509,751	184.0 kb	Distal (>10kb) Multiome	670
chr19:45,528,315–45,529,353	163.8 kb	Distal (>10kb) Multiome	425
chr19:45,584,026–45,585,251	108.0 kb	Distal (>10kb) Multiome	907
chr19:45,607,096–45,607,695	85.2 kb	Distal (>10kb) Multiome	526
chr19:45,615,654–45,616,944	76.5 kb	Distal (>10kb) Multiome	480
chr19:45,632,406–45,633,148	59.9 kb	Distal (>10kb) Multiome	358
chr19:45,638,965–45,639,696	53.3 kb	Distal (>10kb) Multiome	477
chr19:45,640,813–45,642,557	50.4 kb	Distal (>10kb) Multiome	865
chr19:45,643,187–45,644,012	49.1 kb	Distal (>10kb) Multiome	542
chr19:45,645,389–45,646,343	46.8 kb	Distal (>10kb) Multiome	566
chr19:45,667,856–45,668,417	24.6 kb	Distal (>10kb) Multiome	386
chr19:45,668,914–45,669,719	23.3 kb	Distal (>10kb) Multiome	611
chr19:45,670,481–45,671,446	21.6 kb	Distal (>10kb) Multiome	361
chr19:45,676,875–45,678,209	15.1 kb	Distal (>10kb) Multiome	418
chr19:45,681,530–45,682,004	11.0 kb	Distal (>10kb) Multiome	648
chr19:45,691,622–45,693,062	283 bp	At TSS Multiome	943
chr19:45,693,387–45,693,768	722 bp	At TSS	354
chr19:45,716,851–45,718,343	24.9 kb	Distal (>10kb) Multiome	895
chr19:45,730,200–45,731,219	38.3 kb	Distal (>10kb) Multiome	740
chr19:45,767,223–45,771,892	76.8 kb	Distal (>10kb) Multiome	1161
chr19:45,779,258–45,780,150	86.9 kb	Distal (>10kb) Multiome	445
chr19:45,792,338–45,793,273	100.2 kb	Distal (>10kb) Multiome	609
chr19:45,815,484–45,818,073	123.2 kb	Distal (>10kb) Multiome	623
chr19:45,862,559–45,864,765	171.8 kb	Distal (>10kb) Multiome	976
chr19:45,881,480–45,883,645	189.5 kb	Distal (>10kb) Multiome	990
chr19:45,885,092–45,887,294	194.0 kb	Distal (>10kb) Multiome	913
chr19:45,901,212–45,903,471	210.2 kb	Distal (>10kb) Multiome	780
chr19:45,952,967–45,953,485	260.4 kb	Distal (>10kb) Multiome	329
chr19:45,973,761–45,974,227	281.4 kb	Distal (>10kb) Multiome	201

Genome Browser

Genomic view of the QPCTL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.