Transcription factors with Perturb-seq knockdown data for PYCR1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PYCR1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PYCR1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,923,285–81,923,863 | 8.5 kb | Proximal (<10kb) | 399 | |
| chr17:81,924,942–81,925,146 | 7.3 kb | Proximal (<10kb) | 273 | |
| chr17:81,926,141–81,929,133 | 3.3 kb | Proximal (<10kb) | 1034 | |
| chr17:81,936,855–81,937,682 | 4.5 kb | Proximal (<10kb) | 854 |
Genomic view of the PYCR1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.