Enables nucleosome binding activity. Involved in DNA repair and chromatin organization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PWWP3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PWWP3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PWWP3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:1,061,840–1,062,923 | 292.4 kb | Distal (>10kb) Multiome | 204 | |
| chr19:1,063,045–1,065,722 | 290.1 kb | Distal (>10kb) Multiome | 681 | |
| chr19:1,066,682–1,067,587 | 287.7 kb | Distal (>10kb) Multiome | 489 | |
| chr19:1,071,107–1,071,721 | 283.8 kb | Distal (>10kb) Multiome | 178 | |
| chr19:1,081,317–1,083,172 | 272.5 kb | Distal (>10kb) Multiome | 484 | |
| chr19:1,094,985–1,095,654 | 259.5 kb | Distal (>10kb) Multiome | 671 | |
| chr19:1,103,487–1,105,654 | 250.9 kb | Distal (>10kb) Multiome | 849 | |
| chr19:1,112,029–1,112,884 | 242.6 kb | Distal (>10kb) Multiome | 294 | |
| chr19:1,113,014–1,114,139 | 241.4 kb | Distal (>10kb) Multiome | 690 | |
| chr19:1,122,934–1,123,720 | 231.7 kb | Distal (>10kb) Multiome | 231 | |
| chr19:1,173,441–1,174,438 | 180.7 kb | Distal (>10kb) Multiome | 682 | |
| chr19:1,194,370–1,194,985 | 160.3 kb | Distal (>10kb) Multiome | 531 | |
| chr19:1,205,175–1,206,374 | 149.3 kb | Distal (>10kb) Multiome | 746 | |
| chr19:1,237,080–1,238,434 | 116.8 kb | Distal (>10kb) Multiome | 430 | |
| chr19:1,239,513–1,242,539 | 113.2 kb | Distal (>10kb) Multiome | 889 | |
| chr19:1,244,253–1,244,857 | 110.3 kb | Distal (>10kb) Multiome | 590 | |
| chr19:1,247,981–1,252,501 | 103.9 kb | Distal (>10kb) Multiome | 1136 | |
| chr19:1,259,185–1,262,955 | 95.5 kb | Distal (>10kb) Multiome | 1070 | |
| chr19:1,265,280–1,270,235 | 85.6 kb | Distal (>10kb) Multiome | 1171 | |
| chr19:1,274,423–1,276,502 | 79.2 kb | Distal (>10kb) Multiome | 967 | |
| chr19:1,285,317–1,286,108 | 69.1 kb | Distal (>10kb) Multiome | 277 | |
| chr19:1,354,303–1,355,411 | 41 bp | At TSS Multiome | 688 | |
| chr19:1,383,122–1,384,333 | 28.7 kb | Distal (>10kb) Multiome | 1228 | |
| chr19:1,401,101–1,401,839 | 46.6 kb | Distal (>10kb) Multiome | 540 | |
| chr19:1,406,589–1,408,783 | 52.5 kb | Distal (>10kb) Multiome | 911 | |
| chr19:1,415,008–1,415,721 | 60.6 kb | Distal (>10kb) Multiome | 597 | |
| chr19:1,437,988–1,438,998 | 83.4 kb | Distal (>10kb) Multiome | 1076 | |
| chr19:1,444,785–1,447,383 | 90.3 kb | Distal (>10kb) Multiome | 797 | |
| chr19:1,455,191–1,456,421 | 100.9 kb | Distal (>10kb) Multiome | 491 | |
| chr19:1,468,941–1,469,903 | 114.4 kb | Distal (>10kb) Multiome | 242 | |
| chr19:1,470,088–1,471,597 | 115.8 kb | Distal (>10kb) Multiome | 544 | |
| chr19:1,478,772–1,479,848 | 124.4 kb | Distal (>10kb) Multiome | 857 | |
| chr19:1,489,566–1,491,829 | 136.0 kb | Distal (>10kb) Multiome | 836 | |
| chr19:1,507,230–1,508,699 | 153.2 kb | Distal (>10kb) Multiome | 596 | |
| chr19:1,512,960–1,513,686 | 158.3 kb | Distal (>10kb) Multiome | 541 | |
| chr19:1,523,798–1,524,624 | 169.1 kb | Distal (>10kb) Multiome | 263 | |
| chr19:1,566,277–1,568,916 | 211.8 kb | Distal (>10kb) Multiome | 748 | |
| chr19:1,592,085–1,593,444 | 237.8 kb | Distal (>10kb) Multiome | 883 | |
| chr19:1,604,859–1,606,501 | 250.7 kb | Distal (>10kb) Multiome | 902 | |
| chr19:1,651,519–1,653,514 | 298.0 kb | Distal (>10kb) Multiome | 909 |
Genomic view of the PWWP3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.