This gene encodes the enzyme peptidyl-tRNA hydrolase. Peptidyl-tRNA hydrolases perform the essential function of recycling peptidyl-tRNAs. Mutations in this gene are associated with autosomal-recessive intellectual disability and parkinsonism. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for PTRHD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTRHD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTRHD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:24,456,964–24,457,548 | 336.2 kb | Distal (>10kb) Multiome HiCAR | 112 | |
| chr2:24,489,608–24,492,569 | 302.4 kb | Distal (>10kb) Multiome HiCAR | 854 | |
| chr2:24,791,115–24,791,348 | 2.0 kb | Proximal (<10kb) | 167 | |
| chr2:24,792,642–24,794,076 | 91 bp | At TSS Multiome | 1010 | |
| chr2:24,821,671–24,822,465 | 28.8 kb | Distal (>10kb) Multiome | 172 | |
| chr2:24,827,474–24,828,282 | 34.4 kb | Distal (>10kb) Multiome | 460 | |
| chr2:24,919,504–24,920,824 | 126.8 kb | Distal (>10kb) Multiome | 431 | |
| chr2:24,971,247–24,972,384 | 178.6 kb | Distal (>10kb) Multiome | 1032 | |
| chr2:25,041,314–25,043,455 | 248.7 kb | Distal (>10kb) Multiome | 743 |
Genomic view of the PTRHD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.