This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for PTP4A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTP4A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTP4A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:141,127,643–141,129,710 | 263.6 kb | Distal (>10kb) Multiome | 851 | |
| chr8:141,305,657–141,306,470 | 86.0 kb | Distal (>10kb) Multiome | 142 | |
| chr8:141,306,734–141,309,264 | 83.5 kb | Distal (>10kb) Multiome | 525 | |
| chr8:141,346,632–141,347,366 | 45.0 kb | Distal (>10kb) Multiome | 369 | |
| chr8:141,351,532–141,352,458 | 40.1 kb | Distal (>10kb) Multiome | 211 | |
| chr8:141,386,839–141,387,225 | 4.8 kb | Proximal (<10kb) | 362 | |
| chr8:141,391,326–141,392,706 | 2 bp | At TSS Multiome | 629 | |
| chr8:141,414,715–141,415,638 | 23.0 kb | Distal (>10kb) Multiome | 339 | |
| chr8:141,417,342–141,418,294 | 25.8 kb | Distal (>10kb) Multiome | 410 |
Genomic view of the PTP4A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.