Transcription factors with Perturb-seq knockdown data for PTOV1-AS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTOV1-AS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTOV1-AS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,850,394–49,852,067 | 7.2 kb | Proximal (<10kb) | 862 | |
| chr19:49,865,368–49,865,584 | 6.1 kb | Proximal (<10kb) | 187 | |
| chr19:49,866,817–49,868,124 | 7.5 kb | Proximal (<10kb) | 874 | |
| chr19:49,869,068–49,870,398 | 9.8 kb | Proximal (<10kb) | 832 |
Genomic view of the PTOV1-AS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.