PTENP1-AS encodes an antisense RNA (asRNA) of PTENP1, a PTEN (phosphatase and tensin homolog) pseudogene. PTENP1 regulates PTEN by both sense (GeneID: 11191) and antisense RNAs. This antisense RNA (PTENP1-AS) regulates PTEN transcription and mRNA stability. [provided by RefSeq, Jun 2020]
Transcription factors with Perturb-seq knockdown data for PTENP1-AS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTENP1-AS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTENP1-AS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:33,676,675–33,677,521 | at TSS | At TSS | 242 |
Genomic view of the PTENP1-AS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.