Transcription factors with Perturb-seq knockdown data for PSMG3-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMG3-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMG3-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:1,368,617–1,369,820 | 200.8 kb | Distal (>10kb) Multiome | 421 | |
| chr7:1,412,524–1,413,381 | 157.1 kb | Distal (>10kb) Multiome | 526 | |
| chr7:1,458,555–1,460,310 | 110.4 kb | Distal (>10kb) Multiome | 677 | |
| chr7:1,474,095–1,474,546 | 95.9 kb | Distal (>10kb) Multiome | 567 | |
| chr7:1,504,094–1,504,782 | 65.6 kb | Distal (>10kb) Multiome | 836 | |
| chr7:1,530,385–1,531,336 | 39.4 kb | Distal (>10kb) Multiome | 485 | |
| chr7:1,569,754–1,570,643 | 33 bp | At TSS Multiome | 876 | |
| chr7:1,579,544–1,579,799 | 9.5 kb | Proximal (<10kb) | 300 | |
| chr7:1,664,253–1,667,065 | 94.7 kb | Distal (>10kb) Multiome | 448 | |
| chr7:1,669,081–1,670,862 | 100.0 kb | Distal (>10kb) Multiome | 294 | |
| chr7:1,713,441–1,714,084 | 143.7 kb | Distal (>10kb) Multiome | 662 |
Genomic view of the PSMG3-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.