Transcription factors with Perturb-seq knockdown data for PSMD14-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMD14-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMD14-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:161,159,952–161,161,374 | 90.8 kb | Distal (>10kb) Multiome | 1083 | |
| chr2:161,237,151–161,239,873 | 12.3 kb | Distal (>10kb) Multiome | 760 | |
| chr2:161,244,441–161,245,204 | 6.4 kb | Proximal (<10kb) Multiome | 383 | |
| chr2:161,307,935–161,309,054 | 57.3 kb | Distal (>10kb) Multiome | 1018 | |
| chr2:161,413,932–161,417,535 | 163.5 kb | Distal (>10kb) Multiome | 691 | |
| chr2:161,417,732–161,419,279 | 167.7 kb | Distal (>10kb) Multiome | 374 | |
| chr2:161,422,463–161,424,682 | 172.8 kb | Distal (>10kb) Multiome | 296 |
Genomic view of the PSMD14-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.