This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for PSD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:102,399,132–102,400,002 | 9.3 kb | Proximal (<10kb) | 832 | |
| chr10:102,403,842–102,404,078 | 5.2 kb | Proximal (<10kb) | 275 | |
| chr10:102,408,600–102,409,538 | at TSS | At TSS | 277 | |
| chr10:102,410,213–102,410,909 | 923 bp | At TSS | 148 | |
| chr10:102,418,158–102,422,381 | 8.9 kb | Proximal (<10kb) | 1097 | |
| chr10:102,422,562–102,423,126 | 3.8 kb | Proximal (<10kb) | 721 |
Genomic view of the PSD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.