Predicted to enable prostaglandin F synthase activity and thioredoxin peroxidase activity. Predicted to be involved in prostaglandin biosynthetic process. Located in extracellular exosome and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRXL2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRXL2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRXL2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:2,314,340–2,315,728 | 271.6 kb | Distal (>10kb) Multiome | 557 | |
| chr1:2,391,076–2,392,400 | 195.1 kb | Distal (>10kb) Multiome | 820 | |
| chr1:2,411,953–2,414,836 | 172.4 kb | Distal (>10kb) Multiome | 918 | |
| chr1:2,525,908–2,527,142 | 60.4 kb | Distal (>10kb) Multiome | 668 | |
| chr1:2,529,108–2,529,820 | 57.5 kb | Distal (>10kb) Multiome | 222 | |
| chr1:2,545,676–2,548,580 | 40.6 kb | Distal (>10kb) Multiome | 918 | |
| chr1:2,578,338–2,578,614 | 8.2 kb | Proximal (<10kb) | 541 | |
| chr1:2,585,182–2,587,696 | 184 bp | At TSS Multiome | 748 | |
| chr1:2,642,358–2,643,801 | 56.5 kb | Distal (>10kb) Multiome | 706 |
Genomic view of the PRXL2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.