Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRSS51. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRSS51 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRSS51, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:10,334,318–10,335,970 | 212.8 kb | Distal (>10kb) Multiome | 517 | |
| chr8:10,424,841–10,425,762 | 122.3 kb | Distal (>10kb) Multiome | 275 | |
| chr8:10,547,893–10,548,814 | 665 bp | At TSS Multiome | 258 | |
| chr8:10,572,753–10,573,279 | 25.4 kb | Distal (>10kb) Multiome | 54 | |
| chr8:10,636,412–10,637,239 | 89.1 kb | Distal (>10kb) Multiome | 199 | |
| chr8:10,729,806–10,731,233 | 183.0 kb | Distal (>10kb) Multiome | 304 | |
| chr8:10,732,570–10,733,567 | 185.2 kb | Distal (>10kb) Multiome | 167 | |
| chr8:10,734,083–10,734,837 | 186.9 kb | Distal (>10kb) Multiome | 178 | |
| chr8:10,839,370–10,840,368 | 292.3 kb | Distal (>10kb) Multiome | 844 |
Genomic view of the PRSS51 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.