This gene encodes a large protein of unknown function that contains internal regions of low complexity sequence. Alternative splicing results in multiple transcript variants. The transcript structure of the protein-coding variant at this locus is conserved between human and mouse. [provided by RefSeq, Oct 2013]
Transcription factors with Perturb-seq knockdown data for PRR36. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRR36 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRR36, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,595,485–7,596,417 | 278.6 kb | Distal (>10kb) Multiome | 405 | |
| chr19:7,629,285–7,629,891 | 244.7 kb | Distal (>10kb) Multiome | 650 | |
| chr19:7,636,753–7,637,571 | 237.3 kb | Distal (>10kb) Multiome | 689 | |
| chr19:7,680,480–7,681,546 | 193.6 kb | Distal (>10kb) Multiome | 679 | |
| chr19:7,829,238–7,830,666 | 44.5 kb | Distal (>10kb) Multiome | 621 | |
| chr19:7,853,168–7,853,781 | 20.9 kb | Distal (>10kb) Multiome | 747 | |
| chr19:7,861,607–7,864,383 | 11.7 kb | Distal (>10kb) Multiome | 348 | |
| chr19:7,868,454–7,870,252 | 5.5 kb | Proximal (<10kb) Multiome | 721 | |
| chr19:7,871,072–7,872,772 | 2.3 kb | Proximal (<10kb) Multiome | 487 | |
| chr19:7,873,962–7,875,061 | 198 bp | At TSS Multiome | 416 | |
| chr19:7,888,334–7,888,798 | 14.1 kb | Distal (>10kb) Multiome | 509 | |
| chr19:7,902,730–7,904,931 | 29.3 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:7,917,358–7,918,182 | 43.5 kb | Distal (>10kb) Multiome | 316 | |
| chr19:7,919,934–7,921,640 | 46.3 kb | Distal (>10kb) Multiome | 802 | |
| chr19:7,924,612–7,926,698 | 51.9 kb | Distal (>10kb) Multiome | 766 | |
| chr19:7,943,338–7,944,472 | 69.4 kb | Distal (>10kb) Multiome | 974 | |
| chr19:8,001,954–8,002,874 | 128.1 kb | Distal (>10kb) Multiome | 475 | |
| chr19:8,005,202–8,006,197 | 131.4 kb | Distal (>10kb) Multiome | 729 | |
| chr19:8,050,174–8,051,154 | 176.3 kb | Distal (>10kb) Multiome | 467 | |
| chr19:8,148,316–8,149,986 | 275.2 kb | Distal (>10kb) Multiome | 381 |
Genomic view of the PRR36 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.