Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRR13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRR13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRR13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:53,174,900–53,175,484 | 266.5 kb | Distal (>10kb) Multiome | 474 | |
| chr12:53,179,987–53,181,456 | 261.0 kb | Distal (>10kb) Multiome | 930 | |
| chr12:53,219,787–53,222,151 | 220.6 kb | Distal (>10kb) Multiome | 828 | |
| chr12:53,231,703–53,233,098 | 209.4 kb | Distal (>10kb) Multiome | 464 | |
| chr12:53,251,461–53,252,566 | 189.7 kb | Distal (>10kb) Multiome | 825 | |
| chr12:53,268,046–53,268,600 | 173.5 kb | Distal (>10kb) Multiome | 709 | |
| chr12:53,295,142–53,295,823 | 146.3 kb | Distal (>10kb) Multiome | 706 | |
| chr12:53,299,515–53,300,187 | 142.0 kb | Distal (>10kb) Multiome | 849 | |
| chr12:53,321,051–53,322,029 | 120.3 kb | Distal (>10kb) Multiome | 935 | |
| chr12:53,324,682–53,326,037 | 116.8 kb | Distal (>10kb) Multiome | 840 | |
| chr12:53,344,427–53,345,660 | 96.7 kb | Distal (>10kb) Multiome | 645 | |
| chr12:53,370,910–53,371,893 | 70.3 kb | Distal (>10kb) Multiome HiCAR | 861 | |
| chr12:53,378,839–53,381,297 | 61.2 kb | Distal (>10kb) Multiome | 895 | |
| chr12:53,381,689–53,382,262 | 59.7 kb | Distal (>10kb) Multiome | 264 | |
| chr12:53,421,253–53,422,044 | 20.1 kb | Distal (>10kb) Multiome HiCAR | 431 | |
| chr12:53,440,979–53,441,838 | 140 bp | At TSS Multiome | 779 | |
| chr12:53,451,563–53,453,067 | 10.3 kb | Distal (>10kb) Multiome | 999 | |
| chr12:53,492,147–53,494,149 | 51.4 kb | Distal (>10kb) Multiome | 702 | |
| chr12:53,498,714–53,500,111 | 57.7 kb | Distal (>10kb) Multiome | 454 | |
| chr12:53,500,242–53,501,839 | 59.3 kb | Distal (>10kb) Multiome | 1010 | |
| chr12:53,625,664–53,626,787 | 184.5 kb | Distal (>10kb) Multiome | 880 | |
| chr12:53,675,553–53,677,839 | 234.4 kb | Distal (>10kb) Multiome | 1104 | |
| chr12:53,696,162–53,696,648 | 254.8 kb | Distal (>10kb) Multiome | 228 | |
| chr12:53,727,002–53,728,055 | 285.9 kb | Distal (>10kb) Multiome | 768 | |
| chr12:53,738,393–53,738,964 | 296.9 kb | Distal (>10kb) Multiome | 131 |
Genomic view of the PRR13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.