Transcription factors with Perturb-seq knockdown data for PRMT5-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRMT5-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRMT5-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:22,766,419–22,767,375 | 162.9 kb | Distal (>10kb) Multiome | 988 | |
| chr14:22,821,826–22,823,530 | 106.8 kb | Distal (>10kb) Multiome | 649 | |
| chr14:22,852,845–22,853,709 | 76.4 kb | Distal (>10kb) Multiome | 788 | |
| chr14:22,870,967–22,873,202 | 58.0 kb | Distal (>10kb) Multiome | 1167 | |
| chr14:22,882,594–22,883,886 | 46.4 kb | Distal (>10kb) Multiome | 289 | |
| chr14:22,886,371–22,887,824 | 42.5 kb | Distal (>10kb) Multiome | 639 | |
| chr14:22,918,527–22,919,975 | 10.3 kb | Distal (>10kb) Multiome | 641 | |
| chr14:22,928,961–22,930,849 | 1.2 kb | Proximal (<10kb) Multiome | 1108 | |
| chr14:22,933,450–22,933,927 | 3.8 kb | Proximal (<10kb) | 16 | |
| chr14:22,956,530–22,957,512 | 27.5 kb | Distal (>10kb) Multiome | 983 | |
| chr14:22,981,215–22,983,249 | 53.0 kb | Distal (>10kb) Multiome | 935 | |
| chr14:23,006,674–23,007,583 | 77.5 kb | Distal (>10kb) Multiome | 1097 | |
| chr14:23,154,159–23,154,639 | 224.8 kb | Distal (>10kb) Multiome | 392 | |
| chr14:23,161,040–23,161,530 | 231.7 kb | Distal (>10kb) Multiome | 397 | |
| chr14:23,182,495–23,182,942 | 253.1 kb | Distal (>10kb) Multiome | 139 |
Genomic view of the PRMT5-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.