This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018]
Transcription factors with Perturb-seq knockdown data for PRKG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRKG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRKG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:81,030,483–81,032,137 | 122.9 kb | Distal (>10kb) Multiome | 355 | |
| chr4:81,153,491–81,154,408 | at TSS | At TSS | 188 | |
| chr4:81,214,271–81,215,901 | 61.2 kb | Distal (>10kb) Multiome | 315 | |
| chr4:81,365,957–81,366,689 | 212.5 kb | Distal (>10kb) Multiome | 115 | |
| chr4:81,421,371–81,422,293 | 268.2 kb | Distal (>10kb) Multiome | 410 | |
| chr4:81,470,519–81,472,674 | 318.2 kb | Distal (>10kb) Multiome | 675 | |
| chr4:81,486,328–81,487,160 | 333.0 kb | Distal (>10kb) Multiome | 174 |
Genomic view of the PRKG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.