This gene encodes a DNA primase-polymerase that belongs to a superfamily of archaeao-eukaryotic primases. Members of this family have primase activity, catalyzing the synthesis of short RNA primers that serve as starting points for DNA synthesis, as well as DNA polymerase activity. The encoded protein facilitates DNA damage tolerance by mediating uninterrupted fork progression after UV irradiation and reinitiating DNA synthesis. An allelic variant in this gene is associated with myopia 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for PRIMPOL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRIMPOL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRIMPOL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:184,472,503–184,475,460 | 175.0 kb | Distal (>10kb) Multiome | 965 | |
| chr4:184,536,785–184,538,298 | 112.1 kb | Distal (>10kb) Multiome | 704 | |
| chr4:184,625,573–184,626,654 | 23.5 kb | Distal (>10kb) Multiome | 388 | |
| chr4:184,648,062–184,650,476 | 152 bp | At TSS Multiome | 822 | |
| chr4:184,733,143–184,734,876 | 84.5 kb | Distal (>10kb) Multiome | 1145 | |
| chr4:184,814,706–184,816,098 | 165.7 kb | Distal (>10kb) Multiome | 552 | |
| chr4:184,825,249–184,826,846 | 176.3 kb | Distal (>10kb) Multiome | 644 |
Genomic view of the PRIMPOL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.