This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPP6C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP6C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP6C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:124,940,496–124,941,902 | 248.7 kb | Distal (>10kb) Multiome | 979 | |
| chr9:125,142,890–125,144,084 | 46.2 kb | Distal (>10kb) Multiome | 723 | |
| chr9:125,189,173–125,190,290 | 94 bp | At TSS Multiome | 830 | |
| chr9:125,199,947–125,201,039 | 10.8 kb | Distal (>10kb) Multiome | 866 | |
| chr9:125,240,934–125,242,115 | 51.7 kb | Distal (>10kb) Multiome | 974 | |
| chr9:125,261,500–125,262,311 | 72.0 kb | Distal (>10kb) Multiome | 900 | |
| chr9:125,407,852–125,408,856 | 218.5 kb | Distal (>10kb) Multiome | 615 |
Genomic view of the PPP6C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.