The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for PPP4R4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP4R4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP4R4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:93,938,972–93,940,225 | 234.6 kb | Distal (>10kb) Multiome | 431 | |
| chr14:94,026,129–94,026,981 | 148.0 kb | Distal (>10kb) Multiome | 519 | |
| chr14:94,080,803–94,081,695 | 93.1 kb | Distal (>10kb) Multiome | 679 | |
| chr14:94,129,110–94,129,887 | 44.7 kb | Distal (>10kb) Multiome | 322 | |
| chr14:94,173,317–94,175,546 | 165 bp | At TSS Multiome | 517 |
Genomic view of the PPP4R4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.