This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for PPP1R7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:240,902,359–240,903,515 | 246.7 kb | Distal (>10kb) Multiome | 217 | |
| chr2:240,997,873–240,999,416 | 151.1 kb | Distal (>10kb) Multiome | 439 | |
| chr2:241,009,658–241,010,603 | 139.5 kb | Distal (>10kb) Multiome | 314 | |
| chr2:241,102,057–241,102,727 | 47.2 kb | Distal (>10kb) Multiome | 1072 | |
| chr2:241,148,805–241,150,972 | 179 bp | At TSS Multiome | 897 | |
| chr2:241,217,134–241,217,954 | 68.2 kb | Distal (>10kb) Multiome | 700 | |
| chr2:241,272,147–241,273,188 | 123.2 kb | Distal (>10kb) Multiome | 539 | |
| chr2:241,314,756–241,316,790 | 165.9 kb | Distal (>10kb) Multiome | 1143 | |
| chr2:241,354,545–241,355,644 | 205.5 kb | Distal (>10kb) Multiome | 625 | |
| chr2:241,355,946–241,356,875 | 206.6 kb | Distal (>10kb) Multiome | 680 |
Genomic view of the PPP1R7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.