This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for PPP1R3F. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R3F upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R3F, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:49,001,538–49,002,676 | 267.4 kb | Distal (>10kb) Multiome | 540 | |
| chrX:49,039,840–49,040,493 | 229.7 kb | Distal (>10kb) Multiome | 436 | |
| chrX:49,042,954–49,044,182 | 226.2 kb | Distal (>10kb) Multiome | 664 | |
| chrX:49,053,328–49,054,050 | 216.1 kb | Distal (>10kb) Multiome | 403 | |
| chrX:49,071,863–49,072,612 | 197.7 kb | Distal (>10kb) Multiome | 107 | |
| chrX:49,073,903–49,074,451 | 195.7 kb | Distal (>10kb) Multiome | 464 | |
| chrX:49,100,885–49,101,855 | 168.5 kb | Distal (>10kb) Multiome | 562 | |
| chrX:49,155,633–49,156,658 | 113.6 kb | Distal (>10kb) Multiome | 524 | |
| chrX:49,163,555–49,164,377 | 105.8 kb | Distal (>10kb) Multiome | 485 | |
| chrX:49,166,140–49,166,713 | 103.3 kb | Distal (>10kb) Multiome | 416 | |
| chrX:49,184,219–49,185,254 | 85.2 kb | Distal (>10kb) Multiome | 389 | |
| chrX:49,186,113–49,186,660 | 83.3 kb | Distal (>10kb) Multiome | 589 | |
| chrX:49,190,730–49,191,899 | 78.6 kb | Distal (>10kb) Multiome | 636 | |
| chrX:49,199,793–49,200,448 | 69.6 kb | Distal (>10kb) Multiome | 806 | |
| chrX:49,230,792–49,231,268 | 38.7 kb | Distal (>10kb) Multiome | 221 | |
| chrX:49,268,786–49,270,236 | 426 bp | At TSS Multiome | 603 |
Genomic view of the PPP1R3F locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.