Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]
Transcription factors with Perturb-seq knockdown data for PPP1R1C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R1C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R1C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:181,656,181–181,658,869 | 296.9 kb | Distal (>10kb) Multiome | 546 | |
| chr2:181,677,659–181,678,624 | 276.3 kb | Distal (>10kb) Multiome | 585 | |
| chr2:181,680,198–181,681,989 | 273.7 kb | Distal (>10kb) Multiome | 316 | |
| chr2:181,682,538–181,684,472 | 270.7 kb | Distal (>10kb) Multiome | 355 | |
| chr2:181,803,820–181,804,716 | 150.3 kb | Distal (>10kb) Multiome | 318 | |
| chr2:181,891,152–181,892,949 | 62.7 kb | Distal (>10kb) Multiome | 1077 | |
| chr2:181,953,913–181,954,778 | at TSS | At TSS | 354 | |
| chr2:182,030,718–182,031,289 | at TSS | At TSS | 144 |
Genomic view of the PPP1R1C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.