Transcription factors with Perturb-seq knockdown data for PPP1R12A-AS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R12A-AS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R12A-AS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:79,547,112–79,548,307 | 142.5 kb | Distal (>10kb) Multiome | 725 | |
| chr12:79,682,151–79,682,340 | 7.8 kb | Proximal (<10kb) | 10 | |
| chr12:79,689,372–79,692,289 | 934 bp | At TSS Multiome | 877 | |
| chr12:79,933,910–79,935,979 | 245.0 kb | Distal (>10kb) Multiome | 997 |
Genomic view of the PPP1R12A-AS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.