This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for PPME1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPME1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPME1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:73,876,432–73,877,378 | 294.4 kb | Distal (>10kb) Multiome | 911 | |
| chr11:73,982,330–73,983,905 | 188.1 kb | Distal (>10kb) Multiome | 1122 | |
| chr11:74,170,498–74,171,610 | 129 bp | At TSS Multiome | 881 | |
| chr11:74,311,252–74,311,993 | 140.4 kb | Distal (>10kb) Multiome | 289 | |
| chr11:74,397,796–74,399,222 | 227.4 kb | Distal (>10kb) Multiome | 811 | |
| chr11:74,467,393–74,467,865 | 296.2 kb | Distal (>10kb) Multiome | 174 |
Genomic view of the PPME1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.