Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and regulation of canonical NF-kappaB signal transduction. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPM1N. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPM1N upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPM1N, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:45,234,200–45,234,822 | 262.7 kb | Distal (>10kb) Multiome | 105 | |
| chr19:45,250,821–45,251,491 | 246.0 kb | Distal (>10kb) Multiome | 397 | |
| chr19:45,340,431–45,341,201 | 156.4 kb | Distal (>10kb) Multiome | 363 | |
| chr19:45,370,064–45,371,122 | 126.6 kb | Distal (>10kb) Multiome | 592 | |
| chr19:45,402,280–45,402,828 | 94.7 kb | Distal (>10kb) Multiome | 332 | |
| chr19:45,403,781–45,404,684 | 93.2 kb | Distal (>10kb) Multiome | 494 | |
| chr19:45,404,818–45,406,887 | 90.7 kb | Distal (>10kb) Multiome | 964 | |
| chr19:45,423,326–45,424,545 | 73.5 kb | Distal (>10kb) Multiome | 996 | |
| chr19:45,439,539–45,440,189 | 57.4 kb | Distal (>10kb) Multiome | 718 | |
| chr19:45,443,052–45,444,768 | 53.7 kb | Distal (>10kb) Multiome | 857 | |
| chr19:45,450,695–45,451,265 | 46.4 kb | Distal (>10kb) Multiome | 515 | |
| chr19:45,455,706–45,456,201 | 41.3 kb | Distal (>10kb) Multiome | 776 | |
| chr19:45,467,169–45,468,696 | 29.5 kb | Distal (>10kb) Multiome | 686 | |
| chr19:45,468,843–45,470,312 | 27.8 kb | Distal (>10kb) Multiome | 769 | |
| chr19:45,478,416–45,479,276 | 18.4 kb | Distal (>10kb) Multiome | 809 | |
| chr19:45,485,144–45,486,070 | 11.7 kb | Distal (>10kb) Multiome | 659 | |
| chr19:45,492,647–45,493,344 | 4.3 kb | Proximal (<10kb) Multiome | 522 | |
| chr19:45,496,247–45,497,677 | 178 bp | At TSS Multiome | 742 | |
| chr19:45,497,784–45,498,132 | 554 bp | At TSS | 18 | |
| chr19:45,498,270–45,499,916 | 2.3 kb | Proximal (<10kb) Multiome | 464 | |
| chr19:45,506,243–45,507,963 | 9.5 kb | Proximal (<10kb) Multiome | 969 | |
| chr19:45,508,291–45,509,751 | 11.4 kb | Distal (>10kb) Multiome | 670 | |
| chr19:45,528,315–45,529,353 | 31.6 kb | Distal (>10kb) Multiome | 425 | |
| chr19:45,584,026–45,585,251 | 87.4 kb | Distal (>10kb) Multiome | 907 | |
| chr19:45,607,096–45,607,695 | 110.2 kb | Distal (>10kb) Multiome | 526 | |
| chr19:45,615,654–45,616,944 | 118.9 kb | Distal (>10kb) Multiome | 480 | |
| chr19:45,632,406–45,633,148 | 135.5 kb | Distal (>10kb) Multiome | 358 | |
| chr19:45,638,965–45,639,696 | 142.1 kb | Distal (>10kb) Multiome | 477 | |
| chr19:45,640,813–45,642,557 | 145.1 kb | Distal (>10kb) Multiome | 865 | |
| chr19:45,643,187–45,644,012 | 146.4 kb | Distal (>10kb) Multiome | 542 | |
| chr19:45,645,389–45,646,343 | 148.7 kb | Distal (>10kb) Multiome | 566 | |
| chr19:45,667,856–45,668,417 | 170.8 kb | Distal (>10kb) Multiome | 386 | |
| chr19:45,668,914–45,669,719 | 172.1 kb | Distal (>10kb) Multiome | 611 | |
| chr19:45,670,481–45,671,446 | 173.8 kb | Distal (>10kb) Multiome | 361 | |
| chr19:45,676,875–45,678,209 | 180.3 kb | Distal (>10kb) Multiome | 418 | |
| chr19:45,681,530–45,682,004 | 184.5 kb | Distal (>10kb) Multiome | 648 | |
| chr19:45,691,622–45,693,062 | 195.2 kb | Distal (>10kb) Multiome | 943 | |
| chr19:45,716,851–45,718,343 | 220.3 kb | Distal (>10kb) Multiome | 895 | |
| chr19:45,730,200–45,731,219 | 233.8 kb | Distal (>10kb) Multiome | 740 | |
| chr19:45,767,223–45,771,892 | 272.2 kb | Distal (>10kb) Multiome | 1161 | |
| chr19:45,779,258–45,780,150 | 282.4 kb | Distal (>10kb) Multiome | 445 | |
| chr19:45,792,338–45,793,273 | 295.7 kb | Distal (>10kb) Multiome | 609 |
Genomic view of the PPM1N locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.