This gene encodes the serine/threonine protein phosphatase. The mouse homolog of this gene apparently belongs to the protein phosphatase 2C family of genes. The exact function of this gene is not yet known. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPM1J. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPM1J upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPM1J, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:112,390,678–112,391,531 | 324.3 kb | Distal (>10kb) Multiome HiCAR | 470 | |
| chr1:112,395,753–112,396,890 | 319.1 kb | Distal (>10kb) Multiome HiCAR | 600 | |
| chr1:112,465,931–112,466,532 | 249.0 kb | Distal (>10kb) Multiome | 686 | |
| chr1:112,501,804–112,502,551 | 213.1 kb | Distal (>10kb) Multiome | 420 | |
| chr1:112,507,925–112,508,314 | 207.3 kb | Distal (>10kb) Multiome | 122 | |
| chr1:112,508,429–112,509,558 | 206.6 kb | Distal (>10kb) Multiome | 413 | |
| chr1:112,618,652–112,620,129 | 95.5 kb | Distal (>10kb) Multiome | 956 | |
| chr1:112,674,125–112,675,737 | 40.7 kb | Distal (>10kb) Multiome | 910 | |
| chr1:112,700,203–112,701,476 | 14.5 kb | Distal (>10kb) Multiome | 765 | |
| chr1:112,704,514–112,705,591 | 10.1 kb | Distal (>10kb) Multiome | 694 | |
| chr1:112,706,536–112,707,966 | 8.0 kb | Proximal (<10kb) Multiome | 784 | |
| chr1:112,714,149–112,716,774 | 1.3 kb | Proximal (<10kb) Multiome | 765 | |
| chr1:112,718,742–112,719,144 | 3.4 kb | Proximal (<10kb) | 343 | |
| chr1:112,722,394–112,723,272 | 7.1 kb | Proximal (<10kb) | 178 | |
| chr1:112,743,679–112,744,585 | 28.9 kb | Distal (>10kb) Multiome | 198 | |
| chr1:112,794,180–112,795,498 | 79.8 kb | Distal (>10kb) Multiome | 251 | |
| chr1:112,817,716–112,818,473 | 102.8 kb | Distal (>10kb) Multiome | 249 | |
| chr1:112,849,324–112,850,157 | 134.5 kb | Distal (>10kb) Multiome | 352 | |
| chr1:112,955,281–112,957,849 | 241.0 kb | Distal (>10kb) Multiome | 1108 | |
| chr1:113,072,181–113,073,766 | 357.8 kb | Distal (>10kb) Multiome HiCAR | 975 |
Genomic view of the PPM1J locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.