This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for PPIP5K1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIP5K1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIP5K1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:43,330,217–43,330,762 | 259.7 kb | Distal (>10kb) Multiome | 845 | |
| chr15:43,370,765–43,371,726 | 218.9 kb | Distal (>10kb) Multiome | 774 | |
| chr15:43,492,673–43,493,432 | 97.0 kb | Distal (>10kb) Multiome | 544 | |
| chr15:43,510,550–43,511,326 | 79.3 kb | Distal (>10kb) Multiome | 683 | |
| chr15:43,746,005–43,746,833 | 156.2 kb | Distal (>10kb) Multiome | 588 | |
| chr15:43,776,241–43,777,647 | 187.0 kb | Distal (>10kb) Multiome | 761 | |
| chr15:43,791,747–43,792,642 | 201.9 kb | Distal (>10kb) Multiome | 821 |
Genomic view of the PPIP5K1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.