Predicted to enable RNA polymerase II CTD heptapeptide repeat P3 isomerase activity and RNA polymerase II CTD heptapeptide repeat P6 isomerase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PPIL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:109,186,108–109,187,056 | 254.2 kb | Distal (>10kb) Multiome HiCAR | 39 | |
| chr6:109,236,275–109,236,762 | 204.0 kb | Distal (>10kb) Multiome | 258 | |
| chr6:109,381,700–109,383,452 | 58.0 kb | Distal (>10kb) Multiome | 1036 | |
| chr6:109,440,119–109,441,745 | 100 bp | At TSS Multiome | 863 | |
| chr6:109,454,912–109,456,586 | 15.3 kb | Distal (>10kb) Multiome HiCAR | 733 | |
| chr6:109,482,359–109,484,058 | 42.8 kb | Distal (>10kb) Multiome | 675 | |
| chr6:109,690,198–109,691,786 | 250.6 kb | Distal (>10kb) Multiome | 761 |
Genomic view of the PPIL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.