PPIE

peptidylprolyl isomerase E | CyP-33, CypE, MGC111222, MGC3736

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]

Member of: DE-1

Biological processes 34 terms

RNA binding (GO:0003723)RNA binding (GO:0003723)RNA binding (GO:0003723)U2-type catalytic step 2 spliceosome (GO:0071007)catalytic step 2 spliceosome (GO:0071013)catalytic step 2 spliceosome (GO:0071013)cyclosporin A binding (GO:0016018)cyclosporin A binding (GO:0016018)cytoplasm (GO:0005737)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)intracellular membrane-bounded organelle (GO:0043231)mRNA binding (GO:0003729)mRNA splicing, via spliceosome (GO:0000398)mRNA splicing, via spliceosome (GO:0000398)mRNA splicing, via spliceosome (GO:0000398)mRNA splicing, via spliceosome (GO:0000398)nuclear speck (GO:0016607)nucleic acid binding (GO:0003676)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)peptidyl-prolyl cis-trans isomerase activity (GO:0003755)peptidyl-prolyl cis-trans isomerase activity (GO:0003755)peptidyl-prolyl cis-trans isomerase activity (GO:0003755)peptidyl-prolyl cis-trans isomerase activity (GO:0003755)poly(A) binding (GO:0008143)positive regulation of viral genome replication (GO:0045070)protein binding (GO:0005515)protein folding (GO:0006457)protein folding (GO:0006457)protein-containing complex (GO:0032991)regulation of DNA-templated transcription (GO:0006355)secretory granule lumen (GO:0034774)

Expression (TPM)

TFs regulating PPIE 0 TFs

Transcription factors with Perturb-seq knockdown data for PPIE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PPIE

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:39,490,877–39,492,177	247.3 kb	Distal (>10kb) Multiome	495
chr1:39,576,409–39,577,232	162.0 kb	Distal (>10kb) Multiome	683
chr1:39,609,639–39,610,339	129.0 kb	Distal (>10kb) Multiome	387
chr1:39,632,749–39,633,322	105.8 kb	Distal (>10kb) Multiome	174
chr1:39,639,353–39,640,336	99.1 kb	Distal (>10kb) Multiome	503
chr1:39,691,164–39,691,639	47.4 kb	Distal (>10kb) Multiome	333
chr1:39,701,474–39,702,144	37.0 kb	Distal (>10kb) Multiome	352
chr1:39,738,639–39,739,177	21 bp	At TSS Multiome	534
chr1:39,788,434–39,789,609	50.2 kb	Distal (>10kb) Multiome	548
chr1:39,883,104–39,883,825	144.6 kb	Distal (>10kb) Multiome	732
chr1:39,898,602–39,899,404	160.2 kb	Distal (>10kb) Multiome	394
chr1:39,900,435–39,902,736	161.8 kb	Distal (>10kb) Multiome	848
chr1:39,922,214–39,922,725	183.7 kb	Distal (>10kb) Multiome	180
chr1:39,954,782–39,955,493	216.2 kb	Distal (>10kb) Multiome	479

Genome Browser

Genomic view of the PPIE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.