The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for PPIB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,045,892–64,046,997 | 116.6 kb | Distal (>10kb) Multiome | 442 | |
| chr15:64,093,386–64,094,387 | 69.2 kb | Distal (>10kb) Multiome | 765 | |
| chr15:64,095,741–64,096,612 | 67.2 kb | Distal (>10kb) Multiome | 839 | |
| chr15:64,146,930–64,147,642 | 15.9 kb | Distal (>10kb) Multiome | 403 | |
| chr15:64,151,111–64,152,828 | 11.5 kb | Distal (>10kb) Multiome | 586 | |
| chr15:64,152,948–64,154,154 | 9.4 kb | Proximal (<10kb) Multiome | 593 | |
| chr15:64,162,530–64,163,834 | 59 bp | At TSS Multiome | 876 | |
| chr15:64,355,477–64,356,649 | 193.1 kb | Distal (>10kb) Multiome HiCAR | 748 | |
| chr15:64,381,037–64,381,737 | 218.4 kb | Distal (>10kb) Multiome HiCAR | 630 | |
| chr15:64,387,554–64,388,126 | 224.6 kb | Distal (>10kb) Multiome HiCAR | 1137 | |
| chr15:64,430,220–64,430,746 | 267.3 kb | Distal (>10kb) Multiome | 350 | |
| chr15:64,460,117–64,462,256 | 298.8 kb | Distal (>10kb) Multiome | 930 |
Genomic view of the PPIB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.