The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for PPAN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPAN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPAN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,818,302–9,820,113 | 287.0 kb | Distal (>10kb) Multiome | 870 | |
| chr19:9,827,304–9,828,194 | 278.5 kb | Distal (>10kb) Multiome | 742 | |
| chr19:9,834,598–9,835,806 | 271.3 kb | Distal (>10kb) Multiome | 681 | |
| chr19:9,913,549–9,914,444 | 192.6 kb | Distal (>10kb) Multiome | 322 | |
| chr19:9,914,501–9,914,999 | 191.5 kb | Distal (>10kb) Multiome | 587 | |
| chr19:9,933,993–9,934,841 | 172.0 kb | Distal (>10kb) Multiome | 425 | |
| chr19:9,935,627–9,937,234 | 169.9 kb | Distal (>10kb) Multiome | 297 | |
| chr19:10,027,570–10,028,022 | 78.5 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,086,000–10,086,942 | 20.1 kb | Distal (>10kb) Multiome | 614 | |
| chr19:10,095,848–10,096,951 | 10.1 kb | Distal (>10kb) Multiome | 572 | |
| chr19:10,099,062–10,099,256 | 7.1 kb | Proximal (<10kb) | 250 | |
| chr19:10,106,123–10,106,748 | 21 bp | At TSS Multiome | 842 | |
| chr19:10,113,011–10,113,478 | 6.8 kb | Proximal (<10kb) Multiome | 511 | |
| chr19:10,119,464–10,120,287 | 13.6 kb | Distal (>10kb) Multiome | 818 | |
| chr19:10,194,229–10,195,372 | 88.6 kb | Distal (>10kb) Multiome | 939 | |
| chr19:10,230,671–10,231,665 | 125.0 kb | Distal (>10kb) Multiome | 595 | |
| chr19:10,251,723–10,252,663 | 145.7 kb | Distal (>10kb) Multiome | 969 | |
| chr19:10,269,513–10,270,051 | 163.3 kb | Distal (>10kb) Multiome | 523 | |
| chr19:10,270,913–10,271,370 | 164.8 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,286,849–10,287,511 | 180.7 kb | Distal (>10kb) Multiome | 621 | |
| chr19:10,288,709–10,290,833 | 182.5 kb | Distal (>10kb) Multiome | 688 | |
| chr19:10,292,085–10,293,198 | 186.1 kb | Distal (>10kb) Multiome | 441 | |
| chr19:10,315,359–10,316,478 | 209.6 kb | Distal (>10kb) Multiome | 830 | |
| chr19:10,332,816–10,334,107 | 227.2 kb | Distal (>10kb) Multiome | 882 | |
| chr19:10,334,573–10,335,642 | 228.7 kb | Distal (>10kb) Multiome | 584 | |
| chr19:10,352,359–10,354,435 | 246.3 kb | Distal (>10kb) Multiome | 447 | |
| chr19:10,380,209–10,381,218 | 274.3 kb | Distal (>10kb) Multiome | 874 | |
| chr19:10,403,282–10,404,914 | 297.3 kb | Distal (>10kb) Multiome | 794 |
Genomic view of the PPAN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.