This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for PORCN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PORCN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PORCN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:47,836,213–47,837,023 | 672.3 kb | Distal (>10kb) Multiome HiCAR | 544 | |
| chrX:48,021,260–48,021,892 | 487.5 kb | Distal (>10kb) Multiome HiCAR | 345 | |
| chrX:48,071,368–48,072,042 | 437.2 kb | Distal (>10kb) Multiome HiCAR | 269 | |
| chrX:48,475,845–48,476,469 | 32.8 kb | Distal (>10kb) Multiome | 613 | |
| chrX:48,508,766–48,509,247 | 74 bp | At TSS Multiome | 400 | |
| chrX:48,521,369–48,522,158 | 12.8 kb | Distal (>10kb) Multiome | 519 | |
| chrX:48,539,185–48,540,294 | 30.7 kb | Distal (>10kb) Multiome | 658 | |
| chrX:48,574,090–48,575,023 | 65.6 kb | Distal (>10kb) Multiome | 779 | |
| chrX:48,597,350–48,598,476 | 88.9 kb | Distal (>10kb) Multiome | 660 | |
| chrX:48,676,132–48,677,132 | 167.6 kb | Distal (>10kb) Multiome | 642 | |
| chrX:48,695,862–48,697,105 | 187.7 kb | Distal (>10kb) Multiome | 600 | |
| chrX:48,737,116–48,737,756 | 228.4 kb | Distal (>10kb) Multiome | 580 | |
| chrX:48,801,126–48,802,845 | 292.9 kb | Distal (>10kb) Multiome | 734 |
Genomic view of the PORCN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.