Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POP7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POP7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POP7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,428,059–100,431,175 | 277.2 kb | Distal (>10kb) Multiome | 1296 | |
| chr7:100,435,379–100,436,927 | 269.6 kb | Distal (>10kb) Multiome | 931 | |
| chr7:100,450,379–100,450,973 | 255.4 kb | Distal (>10kb) Multiome | 785 | |
| chr7:100,478,582–100,479,753 | 226.7 kb | Distal (>10kb) Multiome | 842 | |
| chr7:100,482,937–100,484,533 | 222.5 kb | Distal (>10kb) Multiome | 677 | |
| chr7:100,538,557–100,539,759 | 167.1 kb | Distal (>10kb) Multiome | 858 | |
| chr7:100,542,221–100,542,986 | 163.4 kb | Distal (>10kb) Multiome | 274 | |
| chr7:100,569,177–100,570,642 | 136.5 kb | Distal (>10kb) Multiome | 855 | |
| chr7:100,585,161–100,587,241 | 119.7 kb | Distal (>10kb) Multiome | 966 | |
| chr7:100,611,685–100,612,981 | 93.9 kb | Distal (>10kb) Multiome | 767 | |
| chr7:100,626,427–100,627,057 | 79.4 kb | Distal (>10kb) Multiome | 415 | |
| chr7:100,656,111–100,656,626 | 49.7 kb | Distal (>10kb) Multiome | 653 | |
| chr7:100,673,043–100,674,892 | 32.6 kb | Distal (>10kb) Multiome | 934 | |
| chr7:100,674,996–100,676,406 | 30.2 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,691,570–100,692,163 | 14.2 kb | Distal (>10kb) Multiome | 364 | |
| chr7:100,693,475–100,694,667 | 11.8 kb | Distal (>10kb) Multiome | 607 | |
| chr7:100,705,140–100,706,426 | 193 bp | At TSS Multiome | 962 | |
| chr7:100,827,001–100,828,324 | 121.5 kb | Distal (>10kb) Multiome | 794 | |
| chr7:100,835,906–100,837,766 | 130.7 kb | Distal (>10kb) Multiome HiCAR | 766 | |
| chr7:100,852,057–100,853,190 | 146.4 kb | Distal (>10kb) Multiome HiCAR | 805 | |
| chr7:100,874,652–100,875,664 | 168.9 kb | Distal (>10kb) Multiome | 1020 | |
| chr7:100,888,882–100,891,520 | 183.7 kb | Distal (>10kb) Multiome | 1077 | |
| chr7:100,894,188–100,896,392 | 189.9 kb | Distal (>10kb) Multiome | 609 | |
| chr7:100,896,481–100,897,567 | 191.0 kb | Distal (>10kb) Multiome | 538 |
Genomic view of the POP7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.